解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::The story of how preColumbian civilizations developed goes hand-in-hand with the process of plant domestication by Mesoamerican inhabitants. Here, we present the almost complete sequence of a mitochondrial genome and a partial chloroplast genome from an archaeological maize sample collected at the Valley of Tehuacán, ...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evx048
更新日期:2017-04-01 00:00:00
abstract::The adaptive significance of human brain evolution has been frequently studied through comparisons with other primates. However, the evolution of increased brain size is not restricted to the human lineage but is a general characteristic of primate evolution. Whether or not these independent episodes of increased brai...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evx028
更新日期:2017-03-01 00:00:00
abstract::Perennial ryegrass (Lolium perenne L.) is widely used for forage production in both permanent and temporary grassland systems. To increase yields in perennial ryegrass, recent breeding efforts have been focused on strategies to more efficiently exploit heterosis by hybrid breeding. Cytoplasmic male sterility (CMS) is ...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evw047
更新日期:2017-02-01 00:00:00
abstract::Transposable elements (TEs) constitute a substantial portion of many eukaryotic genomes, and can in principle contribute to evolutionary innovation as well as genomic deterioration. Daphnia pulex serves as a useful model for studying TE dynamics as a potential cause and/or consequence of asexuality. We analyzed insert...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evw302
更新日期:2017-02-01 00:00:00
abstract::Many species are not completely reproductively isolated, resulting in hybridization and genetic introgression. Organellar genomes, such as those derived from mitochondria (mtDNA) and chloroplasts, introgress frequently in natural systems; however, the forces shaping patterns of introgression are not always clear. Here...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evw254
更新日期:2017-01-01 00:00:00
abstract::The globin gene family encodes oxygen-binding hemeproteins conserved across the major branches of multicellular life. The origins and evolutionary histories of complete globin repertoires have been established for many vertebrates, but there remain major knowledge gaps for ray-finned fish. Therefore, we used phylogene...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evw266
更新日期:2017-01-01 00:00:00
abstract::Chaperonins promote protein folding and are known to play a role in the maintenance of cellular stability under stress conditions. The group I bacterial chaperonin complex comprises GroEL, that forms a barrel-like oligomer, and GroES that forms the lid. In most eubacteria the GroES/GroEL chaperonin is encoded by a sin...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evw287
更新日期:2017-01-01 00:00:00
abstract::Great genetic variability among teleost immunomes, with gene losses and expansions of central adaptive and innate components, has been discovered through genome sequencing over the last few years. Here, we demonstrate that the innate Myxovirus resistance gene (Mx) is lost from the ancestor of Gadiformes and the closel...
journal_title:Genome biology and evolution
pub_type: 信件
doi:10.1093/gbe/evw250
更新日期:2016-12-31 00:00:00
abstract::We previously discovered that lagging strand genes evolve faster in Bacillus subtilis (and potentially other bacteria). Lagging strand genes are transcribed in the head-on orientation with respect to DNA replication, leading to collisions between the two machineries that stall replication and can destabilize genomes. ...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evw274
更新日期:2016-12-01 00:00:00
abstract::Parasites are sometimes able to manipulate the behavior of their hosts. However, the molecular cues underlying this phenomenon are poorly documented. We previously reported that the parasitoid wasp Leptopilina boulardi which develops from Drosophila larvae is often infected by an inherited DNA virus. In addition to be...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evw277
更新日期:2016-12-01 00:00:00
abstract::Nested genes are the most common form of protein-coding overlap in eukaryotic genomes. Previous studies have shown that nested genes accumulate rapidly over evolutionary time, typically via the insertion of short young duplicate genes into long introns. However, the evolutionary relationship between nested genes remai...
journal_title:Genome biology and evolution
pub_type: 信件
doi:10.1093/gbe/evw237
更新日期:2016-10-23 00:00:00
abstract::"Candidatus Endomicrobium trichonymphae" (Bacteria; Elusimicrobia) is an obligate intracellular symbiont of the cellulolytic protist genus Trichonympha in the termite gut. A previous genome analysis of "Ca Endomicrobium trichonymphae" phylotype Rs-D17 (genomovar Ri2008), obtained from a Trichonympha agilis cell in the...
journal_title:Genome biology and evolution
pub_type: 信件
doi:10.1093/gbe/evw227
更新日期:2016-10-13 00:00:00
abstract::One of the striking features of many eukaryotes is the apparent amount of redundancy in coding and non-coding elements of their genomes. Despite the possible evolutionary advantages, there are fewer examples of redundant sequences in viral genomes, particularly those with RNA genomes. The factors constraining the main...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evw219
更新日期:2016-10-12 00:00:00
abstract::Some photosynthetic organisms live in extremely low light environments. Light limitation is associated with selective forces as well as reduced exposure to mutagens, and over evolutionary timescales it can leave a footprint on species' genomes. Here, we present the chloroplast genomes of four green algae (Bryopsidales...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evw206
更新日期:2016-10-05 00:00:00
abstract::Thousands of candidate human-specific regulatory sequences (HSRS) have been identified, supporting the hypothesis that unique to human phenotypes result from human-specific alterations of genomic regulatory networks. Collectively, a compendium of multiple diverse families of HSRS that are functionally and structurally...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evw185
更新日期:2016-09-19 00:00:00
abstract::Cnidarians represent one of the few groups of venomous animals that lack a centralized venom transmission system. Instead, they are equipped with stinging capsules collectively known as nematocysts. Nematocysts vary in abundance and type across different tissues; however, the venom composition in most species remains ...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evw155
更新日期:2016-08-25 00:00:00
abstract::Recently, a new Chlamydia-related organism, Protochlamydia naegleriophila KNic, was discovered within a Naegleria amoeba. To decipher the mechanisms at play in the modeling of genomes from the Protochlamydia genus, we sequenced the full genome of Pr. naegleriophila, which includes a 2,885,090 bp chromosome and a 145,2...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evw138
更新日期:2016-08-25 00:00:00
abstract::Only few studies on snake venoms were dedicated to deeply characterize the toxin secretion of animals from the Colubridae family, despite the fact that they represent the majority of snake diversity. As a consequence, some evolutionary trends observed in venom proteins that underpinned the evolutionary histories of sn...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evw149
更新日期:2016-08-16 00:00:00
abstract::Polyadenylation is a step of mRNA processing which is crucial for its expression and stability. The major polyadenylation signal (PAS) represents a nucleotide hexamer that adheres to the AATAAA consensus sequence. Over a half of human genes have multiple cleavage and polyadenylation sites, resulting in a great diversi...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evw137
更新日期:2016-07-02 00:00:00
abstract::Natural products from microbes have provided humans with beneficial antibiotics for millennia. However, a decline in the pace of antibiotic discovery exerts pressure on human health as antibiotic resistance spreads, a challenge that may better faced by unveiling chemical diversity produced by microbes. Current microbi...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evw125
更新日期:2016-07-02 00:00:00
abstract::Seed storage proteins (SSP) in cereals provide essential nutrition for humans and animals. Genes encoding these proteins have undergone rapid evolution in different grass species. To better understand the degree of divergence, we analyzed this gene family in the subfamily Chloridoideae, where the genome of teff (Eragr...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evw117
更新日期:2016-06-13 00:00:00
abstract::Cichlid fishes are an ideal model system for studying biological diversification because they provide textbook examples of rapid speciation. To date, there has been little focus on the role of gene regulation during cichlid speciation. However, in recent years, gene regulation has been recognized as a powerful force l...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evw097
更新日期:2016-06-03 00:00:00
abstract::Members from Colletotrichum genus adopt a diverse range of lifestyles during infection of plants and represent a group of agriculturally devastating pathogens. In this study, we present the draft genome of Colletotrichum incanum from the spaethianum clade of Colletotrichum and the comparative analyses with five other ...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evw089
更新日期:2016-05-22 00:00:00
abstract::In the experimental evolution of microbes such as Escherichia coli, many replicate populations are evolved from a common ancestor. Freezing a population sample supplemented with the cryoprotectant glycerol permits later analysis or restarting of an evolution experiment. Typically, each evolving population, and thus ea...
journal_title:Genome biology and evolution
pub_type: 信件
doi:10.1093/gbe/evw054
更新日期:2016-05-09 00:00:00
abstract::The predominantly aquatic order Alismatales, which includes approximately 4,500 species within Araceae, Tofieldiaceae, and the core alismatid families, is a key group in investigating the origin and early diversification of monocots. Despite their importance, phylogenetic ambiguity regarding the root of the Alismatale...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evv260
更新日期:2016-04-06 00:00:00
abstract::Corals belong to the most basal class of the Phylum Cnidaria, which is considered the sister group of bilaterian animals, and thus have become an emerging model to study the evolution of developmental mechanisms. Although cell renewal, differentiation, and maintenance of pluripotency are cellular events shared by mult...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evw042
更新日期:2016-03-23 00:00:00
abstract::Protection against inflammation and oxidative stress is key in slowing down aging processes. The honey bee (Apis mellifera) shows flexible aging patterns linked to the social role of individual bees. One molecular factor associated with honey bee aging regulation is vitellogenin, a lipoglycophosphoprotein with anti-in...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evw014
更新日期:2016-03-09 00:00:00
abstract::Analysis of more than 150 Clostridium botulinum Group II type E genomes identified a small fraction (6%) where neurotoxin-encoding genes were located on plasmids. Seven closely related (134-144 kb) neurotoxigenic plasmids of subtypes E1, E3, and E10 were characterized; all carried genes associated with plasmid mobilit...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evw017
更新日期:2016-03-02 00:00:00
abstract::Plasma membrane NADPH oxidases (NOXs) are key producers of reactive oxygen species under both normal and stress conditions in plants and they form functional subfamilies. Studies of these subfamilies indicated that they show considerable evolutionary selection. We performed a comparative genomic analysis that identifi...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evw035
更新日期:2016-02-23 00:00:00
abstract::Macroevolutionary trends exhibited by retroviruses are complex and not entirely understood. The sloth endogenized foamy-like retrovirus (SloEFV), which demonstrates incongruence in virus-host evolution among extant sloths (Order Folivora), has not been investigated heretofore in any extinct sloth lineages and its prem...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evw023
更新日期:2016-02-14 00:00:00
abstract::SINEs (short interspersed elements) are transposable elements that typically originate independently in each taxonomic clade (order/family). However, some SINE families share a highly similar central sequence and are thus categorized as a SINE superfamily. Although only four SINE superfamilies (CORE-SINEs, V-SINEs, De...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evw029
更新日期:2016-02-12 00:00:00
abstract::Olfactory receptors (ORs) are membrane proteins that mediate the detection of odorants in the environment, and are the largest vertebrate gene family. Comparative studies of mammalian genomes indicate that OR repertoires vary widely, even between closely related lineages, as a consequence of frequent OR gains and loss...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evw013
更新日期:2016-02-09 00:00:00
abstract::In clonal systems, interpreting driver genes in terms of molecular networks helps understanding how these drivers elicit an adaptive phenotype. Obtaining such a network-based understanding depends on the correct identification of driver genes. In clonal systems, independent evolved lines can acquire a similar adaptive...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evw010
更新日期:2016-01-23 00:00:00
abstract::Auxin/indole acetic acids (Aux/IAAs) and auxin response factors (ARFs), major components of the Aux signaling network, are involved in many developmental processes in plants. Investigating their evolution will provide new sight on the relationship between the molecular evolution of these genes and the increasing morph...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evv259
更新日期:2015-12-31 00:00:00
abstract::The genome sequences of the plastid and mitochondrion of white spruce (Picea glauca) were assembled from whole-genome shotgun sequencing data using ABySS. The sequencing data contained reads from both the nuclear and organellar genomes, and reads of the organellar genomes were abundant in the data as each cell harbors...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evv244
更新日期:2015-12-08 00:00:00
abstract::Aspergillus ochraceoroseus and Aspergillus rambellii were isolated from soil detritus in Taï National Park, Ivory Coast, Africa. The Type strain for each species happens to be the only representative ever sampled. Both species secrete copious amounts of aflatoxin B1 and sterigmatocystin, because each of their genomes ...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evv246
更新日期:2015-12-03 00:00:00
abstract::The alphabaculovirus Anticarsia gemmatalis multiple nucleopolyhedrovirus (AgMNPV) is the world's most successful viral bioinsecticide. Through the 1980s and 1990s, this virus was extensively used for biological control of populations of Anticarsia gemmatalis (Velvetbean caterpillar) in soybean crops. During this perio...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evv231
更新日期:2015-11-27 00:00:00
abstract::The large repABC plasmids of the order Rhizobiales with Class I quorum-regulated conjugative transfer systems often define the nature of the bacterium that harbors them. These otherwise diverse plasmids contain a core of highly conserved genes for replication and conjugation raising the question of their evolutionary ...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evv227
更新日期:2015-11-19 00:00:00
abstract::The identification of conserved syntenic regions enables discovery of predicted locations for orthologous and homeologous genes, even when no such gene is present. This capability means that synteny-based methods are far more effective than sequence similarity-based methods in identifying true-negatives, a necessity f...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evv219
更新日期:2015-11-11 00:00:00
abstract::Primary metabolism is essential to plants for growth and development, and secondary metabolism helps plants to interact with the environment. Many plant metabolites are industrially important. These metabolites are produced by plants through complex metabolic pathways. Lack of knowledge about these pathways is hinderi...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evv217
更新日期:2015-11-10 00:00:00